The interplay of microbiota with mucus: (B05)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431232613

We will investigate the bidirectional interplay of microbiota with hydrogel properties and mucosal integrity. We do so in vivo under extrinsic (antibiotic) and intrinsic (gene-deficiency) perturbation, assessing microbiota and mucosa using both high- and low-throughput techniques as well as systems biology modeling. Based on these findings and on other metegenomic data from projects within and outside the consortium, including clinical cohorts, we aim to establish the mucolytic capacity of the microbiota as a predictor for the mucosal physiology/homeostasis in the gastrointestinal tract.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1449: Dynamic Hydrogels at Biointerfaces
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professorin Dr. Sofia Forslund-Startceva; Professor Dr. Marcus Fulde