Analysis of the polycystin-1 signaling module to identify disease modifiers and therapeutic targets for polycystic kidney disease (P05)

• Subject Area: Anatomy and Physiology ; Nephrology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenetic hereditary diseases. Mutations in the genes PKD1 and PKD2 cause ADPKD, but the pathogenic mechanisms remain largely unclear. PKD1 encodes for Polycystin-1, a membrane protein that has been implicated in multiple signal transduction pathways. The goal of this project is to investigate the role of Polycystin-1 in signal transduction using biochemical and genetic methods. These experiments may help to identify novel therapeutic targets for ADPKD.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Michael Köttgen