High-resolution proteomic analysis of native sodium-phosphate transporters SLC34A1 and SLC34A3 and their role in kidney disease (P09)

• Subject Area: Anatomy and Physiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

9 will perform structural and functional analysis of their established NaPi-IIa interactome to investigate the significance and 3D-structure of selected transporter super-complexes, and to unravel the complexome of human brush-border membranes and whole rodent kidney through quantitative proteomic/biochemical analyses of native and heterologously expressed subsets of interactome constituents with NaPi-IIa, functional investigations of the underlying protein-protein interactions, and structural investigations of the identified super-complexes. Thereby, P9 will gain new insights into phosphate handling in the human kidney and diseases resulting from genetic defects thereof.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Bernd Fakler