Interplay between genetic and micro environmental factors in the developmental of renal carcinoma (P14)

• Subject Area: Cell Biology ; Nephrology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

Obesity is a major risk factor for ccRCC. P14 will study the interplay of VHL and PBRM1 mutations and obesity in the development of ccRCC using a set of inducible, renal epithelium-specific, Vhl- and Vhl/Pbrm1-mutant mouse models that allow genetic marking of mutant cells for clonal tracking and cell isolation. In addition to providing fundamental insights into the molecular and cellular mechanisms that underlie renal tumor development, these studies aim to develop the first mouse model of obesity-induced ccRCC that will allow pre-clinical therapeutic intervention studies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Ian Frew