Motor learning-induced plasticity of cerebellar Purkinje neuron connectivity (A04)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431549029

Project A03 addresses the significance of Purkinje cell (PC) synaptic plasticity in accommodating cerebellar cortex connectivity changes underlying motor learning and coordination in a mouse model. A combination of mouse genetics, live imaging, and innovative tracing approaches will be used. Findings will be extended to mouse models suffering from disrupted cerebellar motor learning or ataxia, to disclose the underlying consequences for PC connectivity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1451: Key mechanisms of motor control in health and disease
• Applicant Institution: Universität zu Köln
• Project Head: Matteo Bergami, Ph.D.