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Apraxia in Alzheimer’s disease: Plastic reorganization of praxis networks in response to chronically progressive dysfunction (C04)

Subject Area Molecular and Cellular Neurology and Neuropathology
Human Cognitive and Systems Neuroscience
Term since 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 431549029
 
C04 studies the molecular and functional mechanisms underlying neurodegeneration-induced apraxia and its counteracting reserve mechanisms based on the hypothesis that apraxic deficits in Alzheimer’s disease (AD) are associated with the location and extent of tau-pathology in praxis-related cortical networks. Characterizing apraxia in AD at the behavioural (neuropsychological profiling, including the Cologne apraxia screening, KAS), molecular (Tau-PET imaging), and functional (resting-state fMRI) levels will provide fundamental insights into higher motor functions and may identify specific factors contributing to resilience against apraxia.
DFG Programme Collaborative Research Centres
Applicant Institution Universität zu Köln
 
 

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