Mechanisms of protection from SARS-CoV-2 by neutralizing and non-neutralizing monoclonal antibodies in a small animal model

• Applicant: Professor Dr. Klaus Überla
• Subject Area: Virology ; Immunology
• Term: from 2021 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 458682471

Neutralizing monoclonal antibodies to SARS-CoV2 have been shown to reduce viral load after challenge of passively immunized animals. Since the mechanisms of protection have not been defined the project aims to determine whether Fc-effector mechanisms contribute to protection and whether neutralizing and non-neutralizing antibodies to the SARS-COV-2 spike protein can prevent in vivo the infection of the first cells by viruses from the inocculum.

• DFG Programme: Research Grants