Targeting oncogene-induced DNA repair pathway switches (A09)

• Subject Area: Cell Biology ; Hematology, Oncology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424228829

Reinhardt has identified a cell state transition in KRAS-driven non-small cell lung cancer cells that features a critical change in DNA damage repair competence accompanied with increased mutational burden and altered cancer drug sensitivities. He will unravel the molecular role of proteins of the ubiquilin family that mediate this transition, identify the gene regulatory elements that trigger ubiquilin overexpression and dissect the mechanism and additional targets of the ubiquilins using proteomics. In addition to these mechanistic studies, he will determine thera-peutic vulnerabilities in vitro and in mouse models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1430: Molecular Mechanisms of Cell State Transitions
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Christian Reinhardt