Modulation of the tumor microenvironment by addressing inhibitory (immune) cells via time-programmed and self-regulating liposome (B14*)

• Subject Area: Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

In a humanized mouse model of malignant melanoma, immunomodulation in tumor tissue is addressed, in particular by targeting inhibitory cell populations. pH-responsive liposomes from the previous funding peri-od are further developed into smart, programmable liposomes with time-programmable release and pH-modulating properties in order to selectively release active substances combined with pH-modulation of the tumor microenvironment for intervention in the signaling pathways of mainly macrophages, regulatory T cells (Treg) and tumor cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Mark Helm; Privatdozentin Dr. Andrea Renate Tüttenberg; Professor Dr. Andreas Walther