Microcircuit mechanisms underlying epileptogenesis and behavioural impairment in anti-Drebrin auto-antibody mediated limbic encephalitis (D10*)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

Project D10 will examine key mechanisms of limbic encephalitis (LE) with anti-synaptic autoantibodies, which are increasingly recognized as a possible cause of chronic temporal lobe epilepsy (TLE). The project will use behavioral assessment, chronic EEG and in-vivo imaging techniques over prolonged time periods to address morphological and functional changes in neuronal systems upon antibody exposure, and their role for behavioral impairment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Albert Becker; Privatdozent Dr. Michael Wenzel