Electrochemically driven nickel-catalyzed deaminative strategies in synergy with flow techniques
Final Report Abstract
Within the framework of the DFG-funded research stay, I worked in the group of Prof. Dr. Timothy Noël at the University of Amsterdam focusing on the development of electrochemical methods in combination with flow technology. Electro-organic chemistry has a rich history of development, yet it has not received significant attention from the established synthetic community. However, recent advancements have sparked increased interest among academics in electro-organic procedures. Despite this growing interest, there remain unresolved obstacles, including the need for widespread knowledge of the technology, standardized instruments, tools, protocols, and practical advantages over traditional chemical methods. During my postdoctoral studies at the University of Amsterdam (UvA), the main objective was to expand my electrochemical knowledge with respect to the use of flow technology. Electro-flow chemistry combines flow technology with electro-organic chemistry, enabling precise control of reaction parameters and improving the reproducibility and scalability of electrochemical reactions. Electro-flow chemistry is the sustainable and practical solution, that bridges the gap between academic research and industrial applications. The ambitious premise has always been to move from conventional chemical research to green and environmentally benign alternatives that are also advantageous in practical implementation. During my stay at Prof. Timothy Noël’s lab, I worked on various topics on several projects which exceeded the research objectives outlined in my grant proposal, all of which have recently been published/submitted in peer-reviewed journals.
Publications
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Electrochemical Hydroxylation of Electron‐Rich Arenes in Continuous Flow. European Journal of Organic Chemistry, 2022(20).
Kooli, Anni; Wesenberg, Lars; Beslać, Marko; Krech, Anastasiya; Lopp, Margus; Noël, Timothy & Ošeka, Maksim
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Electrosynthesis of Aryliminophosphoranes in Continuous Flow. Advanced Synthesis & Catalysis, 366(4), 955-960.
Costa, e. Silva Rodrigo; Vega, Clara; Regnier, Morgan; Capaldo, Luca; Wesenberg, Lars; Lowe, Grace; Thiago, de Oliveira Kleber & Noël, Timothy
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Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides. The Journal of Organic Chemistry, 89(22), 16121-16125.
Wesenberg, Lars J.; Sivo, Alessandra; Vilé, Gianvito & Noël, Timothy
