Delivery platforms for antiviral and anti-inflammatory agents targeting infections of respiratory viruses with pandemic potential (D02*)

• Subject Area: Pharmacology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

Influenza A viruses and SARS-CoV-2 cause global health problems. Established factors involved in viral replication, antiviral defence or inflammation are considered attractive targets for pharmaceutical treatment strategies. We will design tailor-made nanoparticles for compounds with limited cell-permeation. We will use an available and highly scalable synthetic antiviral drug, a natural anti-inflammatory drug, or inhibitors for viral uptake and viral uncoating. These nanoparticles will be characterised for their functionality in cellular systems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professorin Dr. Christina Ehrhardt; Professor Dr. Carsten Hoffmann; Professorin Dr. Bettina Löffler; Dr. Stephanie Schubert