Project Details
Projekt Print View

Clinical and functional characterization of a novel monogenic obesity trait (C09*)

Subject Area Pediatric and Adolescent Medicine
Term since 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838
 
Within this project we aim to characterize a novel monogenic obesity trait in a patient with early-onset obesity carrying a yet undescribed mutation in the ASIP (Agouti signaling peptide) gene locus associated with ectopic ASIP overexpression. For this, we will perform a detailed characterization of the patient and address how the clinical phenotype of the patient might be explained by the mutation. Furthermore, we will investigate the role of ASIP in physiological processes related to obesity in cell culture models and in mouse models. Finally, we will assess in available obesity cohorts whether there are more, so far unidentified patients carrying mutations in the ASIP gene.
DFG Programme Collaborative Research Centres
Applicant Institution Universität Leipzig
 
 

Additional Information

Textvergrößerung und Kontrastanpassung