Ionic regulation of Th17-mediated immune responses to Candida infection (C07*)

• Subject Area: Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210879364

Project C7N will expand the immunological expertise in research area C with a focus on T-cell immunology. The PIs of this project have previously shown that ionic signals, such as Na+ and Ca2+ gradients, are critical for the differentiation and function of murine and human Th17 cells. C7N will now investigate how ionic signals shape anti-fungal immune responses in local and systemic C. albicans infection models in mice and humans. C7N focusses in particular on Th17-cell-mediated immune responses and will identify transcriptional and metabolic factors downstream of ionic signaling as potential molecular target to augment anti-fungal immune responses in vivo.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Martin Väth, Ph.D.; Professorin Dr. Christina Zielinski