Uncovering of molecular mechanisms involved in biofilm-associated peri-implant infections (B02)

• Subject Area: Dentistry, Oral Surgery ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

The aim of the subproject is to elucidate molecular mechanisms and identify robust biomarkers that reliably indicate peri-implant infections. This will be achieved through comprehensive longitudinal studies in patient cohorts, which, for the first time, go beyond analyzing bacterial diversity dynamics and biofilm structure to include metatranscriptomic gene expression, host responses, bacteriophage activity, and metabolite profiling. Validation of these mechanisms and biomarkers in advanced 3D tissue-implant-biofilm models will support the identification of reliable signal patterns for detection systems developed within the CRC. At the same time, integrating individual host immune responses will pave the way for personalized therapeutic strategies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Professorin Dr. Susanne Häußler; Professorin Dr. Yang Li; Professorin Dr. Meike Stiesch