Optical sensors for responsive implants (B03)

• Subject Area: Dentistry, Oral Surgery ; Biological and Biomimetic Chemistry ; Measurement Systems
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

In subproject B03, optical detection systems for the early, local sensing of infection-associated biofilm dysbiosis are developed. Dysbiotic metabolites will be detected by an optical fiber with spectroscopic analysis, furthermore, pH-sensitive hydrogel coatings on implants are studied. In addition, bacteria-specific aptamers will be integrated into a microfluidic platform for read-out by the practitioner as chairside detection system. Prototypes of both detection systems will be validated and iteratively improved using the developed in vitro models as well as patient samples.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Professorin Dr. Janina Bahnemann; Professor Dr. Alexander Heisterkamp; Dr. Katharina Nikutta; Professor Dr. Thomas Scheper, until 12/2025