Active stimulus-responsive implants (B04)

• Subject Area: Biomaterials ; Metallurgical, Thermal and Thermomechanical Treatment of Materials
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

Subproject B04 will develop a stimulus-responsive, implant-associated reaction system, which enables targeted, localized drug release when activated by the practitioner upon clinical signs of infection. To achieve this, a novel implant design will be realized, incorporating a switchable, miniaturized electromagnetic pumping unit for on-demand localized drug delivery via a biocompatible porous channel coating that covers the entire implant surface. Simultaneously, to ensure the required mechanical strength, ultra-fine-grained niobium-zirconium-based materials will be developed, utilizing a controlled internal oxidation process for material strengthening.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Dr.-Ing. Christian Klose; Professor Dr.-Ing. Hans Jürgen Maier; Privatdozent Dr. Philipp-Cornelius Pott; Professor Dr.-Ing. Marc Christopher Wurz