Simulation of biofilm growth and drug-induced degradation (B07)

• Subject Area: Mechanics ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

In subproject B07 biofilm growth as well as biofilm therapy for different implant systems will be numerically simulated using the finite element method (FEM). Flow simulation based on smooth particle hydrodynamics methods (SPH) will be coupled with discrete elements for the description of bacteria. They not only map biofilm/flow conditions near surfaces and interaction relationships for biological and chemical interactions but also provide essential hints for the development of the new sensor-actuator systems. To this end, cellular and molecular interactions in biofilm formation and therapeutic degradation are fundamentally characterized to identify effective drug candidates and validate simulations.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Dr. Szymon Piotr Szafranski; Professor Dr.-Ing. Peter Wriggers