Molecular basis for the virulence of Deformed wing virus (DWV) infections in honey bees (B11*)

• Subject Area: Veterinary Medical Science
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 197785619

DWV infections are considered to be a major cause of honey bee colony collapse. The current DWV strains are supposed to have evolved from apathogenic precursors. The aim of our studies is to decipher the molecular determinants of this emerging virulence. To achieve this goal, we will (I) systematically exchange genes between avirulent and virulent strains, (II) analyze genetic variations and selection of traits after passage in bee pupae, and (III) investigate the functions of the viral leader protein as an RNAi antagonist. The results of the study will provide new insights into the virulence factors of DWV and expand the general knowledge about the current DWV epidemic in honey bees.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1021: RNA Viruses: RNA Metabolism, Host Response and Pathogenesis
• Applicant Institution: Philipps-Universität Marburg
• Co-Applicant Institution: Justus-Liebig-Universität Gießen
• Project Head: Professor Dr. Benjamin Lamp