Chemically and structurally directed shape morphosis in hybrid aerogels for bone tissue engineering - Toward designing smart biomimetic 3D scaffold for bone cancer therapy and bone repair
Synthesis and Properties of Functional Materials
Final Report Abstract
Clinical osteosarcoma treatment involves surgical removal followed by radiotherapy or chemotherapy. However, tumor recurrence and bone loss remain major challenges. Additionally, the limited availability and complex harvesting of autologous grafts hinder bone reconstruction. Therefore, theragenerative materials, combining therapy and regeneration, are urgently needed for efficient treatment. The primary objective of this project is to develop multi-functional 3D-printed hybrid aerogels as scaffold materials for bone tumor management. These aerogels are designed using surface-modified silk fibroin (SF) combined with functional inorganic nanoparticles to achieve dual functionality: high photothermal conversion for tumor ablation and osteogenic properties for bone regeneration. The design leverages surface modification, self-assembly, and advanced 3D printing techniques. The unique self-assembly properties of surface-modified SF in solution, coupled with its hybridization with anisotropic nanomaterials (e.g., electrospun silica nanofibers, photothermally active nanoparticles/ agents such as 2D nanosheets, enable the production of range of multifunctional composite aerogel scaffolds with interconnected and hierarchical porosity and biodegradability. Furthermore, the most promising materials undergo evaluation for their in vitro therapeutic efficacy and bone regeneration capabilities. By integrating 3D printing with innovative materials concept, this project aimed at adressing the critical clinical challenges of bone healing affected by tumor.
Publications
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Fabrication of Antibacterial, Osteo‐Inductor 3D Printed Aerogel‐Based Scaffolds by Incorporation of Drug Laden Hollow Mesoporous Silica Microparticles into the Self‐Assembled Silk Fibroin Biopolymer. Macromolecular Bioscience, 22(4).
Ng, Philipp; Pinho, Ana Rita; Gomes, Maria C.; Demidov, Yan; Krakor, Eva; Grume, Daniela; Herb, Marc; Lê, Khan; Mano, João; Mathur, Sanjay & Maleki, Hajar
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Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications. Advanced Science, 10(23).
Karamikamkar, Solmaz; Yalcintas, Ezgi Pinar; Haghniaz, Reihaneh; de Barros, Natan Roberto; Mecwan, Marvin; Nasiri, Rohollah; Davoodi, Elham; Nasrollahi, Fatemeh; Erdem, Ahmet; Kang, Heemin; Lee, Junmin; Zhu, Yangzhi; Ahadian, Samad; Jucaud, Vadim; Maleki, Hajar; Dokmeci, Mehmet Remzi; Kim, Han‐Jun & Khademhosseini, Ali
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Biomimetic Flexible Electronic Materials from Silk Fibroin-MXene Composites Developed via Mussel-Inspired Chemistry as Wearable Pressure Sensors. ACS Applied Nano Materials, 6(7), 5211-5223.
Paolieri, Matteo; Chen, Zihao; Babu Kadumudi, Firoz; Alehosseini, Morteza; Zorrón, Melanie; Dolatshahi-Pirouz, Alireza & Maleki, Hajar
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MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration. ACS Materials Au, 3(6), 711-726.
Pektas, Hadice Kübra; Demidov, Yan.; Ahvan, Aslin; Abie, Nahal; Georgieva, Veronika S.; Chen, Shiyi; Farè, Silvia; Brachvogel, Bent; Mathur, Sanjay & Maleki, Hajar
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Self-Assembly-Driven Bi2S3Nanobelts Integrated a Silk-Fibroin-Based 3D-Printed Aerogel-Based Scaffold with a Dual-Network Structure for Photothermal Bone Cancer Therapy. Langmuir, 39(12), 4326-4337.
Al-Jawuschi, Noor; Chen, Shiyi; Abie, Nahal; Fischer, Thomas; Fare, Silvia & Maleki, Hajar Homa
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3D Printing of Biocompatible and Antibacterial Silica–Silk–Chitosan-Based Hybrid Aerogel Scaffolds Loaded with Propolis. ACS Applied Bio Materials, 7(12), 7917-7935.
Vaseghi, Akbar; Sadeghizadeh, Majid; Herb, Marc; Grumme, Daniela; Demidov, Yan; Remmler, Torsten & Maleki, Hajar Homa
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Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties. ACS Applied Materials & Interfaces, 16(18), 22809-22827.
Abie, Nahal; Ünlü, Ceyda; Pinho, Ana Rita; Gomes, Maria C.; Remmler, Torsten; Herb, Marc; Grumme, Daniela; Tabesh, Ehsan; Shahbazi, Mohammad-Ali; Mathur, Sanjay; Mano, João F. & Maleki, Hajar
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Diatom-inspired silicification process for development of green flexible silica composite aerogels. Scientific Reports, 14(1).
Tan, Valerie; Berg, Florian & Maleki, Hajar
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Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy. Advanced Science, 11(31).
Zorrón, Melanie; Cabrera, Agustín López; Sharma, Riya; Radhakrishnan, Janani; Abbaszadeh, Samin; Shahbazi, Mohammad‐Ali; Tafreshi, Omid Aghababaei; Karamikamkar, Solmaz & Maleki, Hajar
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Encapsulation of propolis extracted with methylal in the chitosan nanoparticles and its antibacterial and cell cytotoxicity studies. BMC Complementary Medicine and Therapies, 24(1).
Vaseghi, Akbar; Parchin, Reza Ashrafi; Chamanie, Kosar Rezaee; Herb, Marc; Maleki, Hajar & Sadeghizadeh, Majid
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Sustainable biodiesel production using lignin-derived sulfonated carbon aerogels catalyst. International Journal of Sustainable Energy, 43(1).
Al-Hamamre, Zayed; Alnaief, Mohammad; Daameh, Sarah; Yamin, Jehad; Sandouqa, Arwa; Alhammouri, Rasha; Maleki, Hajar & Altarawneh, Ibrahem
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Synthesis, characterization, and performance evaluation of different sulfonated lignin-based carbon catalysts for upgrading waste vegetable oil to biodiesel. Energy Conversion and Management, 325, 119381.
Al-Hamamre, Zayed; Alnaief, Mohammad; Yamin, Jehad; Altarawneh, Ibrahem; Sandouqa, Arwa; Hammouri, Rasha; Nasr, Abdullah; Maleki, Hajar & Shawabkeh, Reyad A.
