Numerische Modellierung der Steuerung der Motilität des menschlichen Magens durch die Hirn-Magen-Achse

• Antragsteller: Dr. Roustem Miftahof
• Fachliche Zuordnung: Gastroenterologie ; Bioinformatik und Theoretische Biologie
• Förderung: Förderung von 2021 bis 2025
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 469698389

• Erstellungsjahr: 2025

Zusammenfassung der Projektergebnisse

Many gastric disorders of the highest clinical relevance are assumed to have their origin in the so-called brain-stomach axis, the coupling between the brain and the mechanical motility of the stomach. However, to date the brain-stomach axis remains poorly understood, which severely limits our ability to improve and design efficient therapies against gastric disorders. The objective of this project is understanding the foundations of the brain-stomach axis by developing in particular computational biology models of the connection between the brain and the stomach and the processes that play key roles in controlling the motility of the stomach through this connection.

Projektbezogene Publikationen (Auswahl)

• A 3D-1D-0D multiscale model of the neuro-glial-vascular unit for synaptic and vascular dynamics in the dorsal vagal complex. Journal of Mathematical Biology, 92(1).
  Hermann, Alexander; Köppl, Tobias; Wagner, Andreas; Shojaei, Arman; Wohlmuth, Barbara; Aydin, Roland; Cyron, Christian J. & Miftahof, Roustem