ElViS - Electrochemical Virus (Covid-19) Sensors based on Printed and Langmuir Blodgett assembled 2D materials; fast, cheap, reliable, point of care devices.
Synthesis and Properties of Functional Materials
Final Report Abstract
I took my Benjamin Walter Fellowship to Northwestern University where I developed Electrochemical Virus Sensor (ElViS) – a fast, low-cost, and reliable biosensor platform for detecting viruses, based on printed 2D materials such as graphene. Motivated by the urgent global need for accessible and accurate diagnostics, I focused on designing a user-friendly device that could be used at the point of care, with minimal sample requirements and no need for invasive procedures. Per the needs of the times, I used SARS-CoV-19 of multiple variants as a target. I successfully formulated stable graphene-based inks and used them to fabricate flexible, screenprinted immunosensors. These sensors, optimized for detecting the SARS-CoV-19 spike protein in saliva, demonstrated exceptionally high sensitivity and specificity using electrochemical impedance spectroscopy. The core results were published in ACS Applied Materials & Interfaces, while broader technological implications were summarized in an invited review in Current Opinion in Solid State and Materials Science. These papers document the sensor development and the broader context of printed nanomaterial platforms for pandemic readiness. The project also fostered collaborations beyond the host lab, particularly with experts in nanomedicine and implantable biosensors, helping shape my long-term research vision at the intersection of 2D materials and biomedical applications. The ElViS project confirmed the viability of scalable, lowcost 2D-material-based biosensors for pandemic response and beyond. I am excited to explore further their potential in diagnostics for broader health and environmental monitoring.
Publications
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Aerosol-jet-printed graphene electrochemical immunosensors for rapid and label-free detection of SARS-CoV-2 in saliva. 2D Materials, 9(3), 035016.
Pola, Cícero C.; Rangnekar, Sonal V.; Sheets, Robert; Szydłowska, Beata M.; Downing, Julia R.; Parate, Kshama W.; Wallace, Shay G.; Tsai, Daphne; Hersam, Mark C.; Gomes, Carmen L. & Claussen, Jonathan C.
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All‐Printed Ultrahigh‐Responsivity MoS2 Nanosheet Photodetectors Enabled by Megasonic Exfoliation. Advanced Materials, 34(34).
Kuo, Lidia; Sangwan, Vinod K.; Rangnekar, Sonal V.; Chu, Ting‐Ching; Lam, David; Zhu, Zhehao; Richter, Lee J.; Li, Ruipeng; Szydłowska, Beata M.; Downing, Julia R.; Luijten, Benjamin J.; Lauhon, Lincoln J. & Hersam, Mark C.
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Liquid-Phase Exfoliation of Magnetically and Optoelectronically Active Ruthenium Trichloride Nanosheets. ACS Nano, 16(7), 11315-11324.
Lam, David; Lebedev, Dmitry; Kuo, Lidia; Sangwan, Vinod K.; Szydłowska, Beata M.; Ferraresi, Filippo; Söll, Aljoscha; Sofer, Zdeněk & Hersam, Mark C.
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Understanding the Photoluminescence Quenching of Liquid Exfoliated WS2 Monolayers. The Journal of Physical Chemistry C, 126(51), 21681-21688.
Li, Zhaojun; Rashvand, Farnia; Bretscher, Hope; Szydłowska, Beata M.; Xiao, James; Backes, Claudia & Rao, Akshay
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Electroluminescence from Megasonically Solution-Processed MoS2 Nanosheet Films. ACS Nano, 17(17), 17516-17526.
Rangnekar, Sonal V.; Sangwan, Vinod K.; Jin, Mengru; Khalaj, Maryam; Szydłowska, Beata M.; Dasgupta, Anushka; Kuo, Lidia; Kurtz, Heather E.; Marks, Tobin J. & Hersam, Mark C.
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Highly conductive and long-term stable films from liquid-phase exfoliated platinum diselenide. Journal of Materials Chemistry C, 11(2), 593-599.
Lee, Kangho; Szydłowska, Beata M.; Hartwig, Oliver; Synnatschke, Kevin; Tywoniuk, Bartlomiej; Hartman, Tomáš; Tomašević-Ilić, Tijana; Gabbett, Cian P.; Coleman, Jonathan N.; Sofer, Zdeněk; Spasenović, Marko; Backes, Claudia & Duesberg, Georg S.
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Printed nanomaterial sensor platforms for COVID-19 and future pandemics. Current Opinion in Solid State and Materials Science, 27(6), 101121.
Szydłowska, Beata M.; Cai, Zizhen & Hersam, Mark C.
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Sonication-assisted liquid exfoliation and size-dependent properties of magnetic two-dimensional α-RuCl3. Journal of Physics D: Applied Physics, 56(27), 274001.
Synnatschke, Kevin; Jonak, Martin; Storm, Alexander; Laha, Sourav; Köster, Janis; Petry, Julian; Ott, Steffen; Szydłowska, Beata; Duesberg, Georg S.; Kaiser, Ute; Klingeler, Rüdiger; Lotsch, Bettina V. & Backes, Claudia
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Biolayer-Interferometry-Guided Functionalization of Screen-Printed Graphene for Label-Free Electrochemical Virus Detection. ACS Applied Materials & Interfaces, 16(19), 25169-25180.
Szydlowska, Beata M.; Pola, Cícero C.; Cai, Zizhen; Chaney, Lindsay E.; Hui, Janan; Sheets, Robert; Carpenter, Jeremiah; Dean, Delphine; Claussen, Jonathan C.; Gomes, Carmen L. & Hersam, Mark C.
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Polydiolcitrate–MoS2 Composite for 3D Printing Radio-Opaque, Bioresorbable Vascular Scaffolds. ACS Applied Materials & Interfaces, 16(34), 45422-45432.
Szydlowska, Beata M.; Ding, Yonghui; Moore, Connor; Cai, Zizhen; Torres-Castanedo, Carlos G.; Collins, Caralyn P.; Jones, Evan; Hersam, Mark C.; Sun, Cheng & Ameer, Guillermo A.
