Biosynthesis of the translation machinery: identification of regulatory factors and mechanisms

• Applicant: Professor Dr. Utz Fischer
• Subject Area: Cell Biology
• Term: from 2007 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 33442413

Final Report Abstract

No abstract available

Publications

• 2008. TDRD3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. Hum.Mol.Genet. 17:3236-46
  Linder, B., Plöttner O., Kroiss, M., Hartmann, E., Laggerbauer, B, Meister, G. and Fischer, U.
  (See online at https://doi.org/10.1093/hmg/ddn219)
• 2008.The La-related protein, Larp7, is a component of the 7SK snRNP and affects Tat-dependent transcription of HIV-1. EMBOrep. 9:569-575
  Markert A, Grimm M, Martinez J, Wiesner J, Meyerhans A, Meyuhas O, Sickmann A, Fischer U
  (See online at https://doi.org/10.1038/embor.2008.72)
• 2010. A stimulatory role for the La-related protein 4B in translation. RNA. 16:1488-99
  Schäffler K, Schulz K, Hirmer A, Wiesner J, Grimm M, Sickmann A, Fischer U
  (See online at https://doi.org/10.1261/rna.2146910)
• 2013. Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci. 16(9):1228-1237
  Stoll G, Pietiläinen OP, Linder B, Suvisaari J, Brosi C, Hennah W, Leppä V, Torniainen M, Ripatti S, Ala-Mello S, Plöttner O, Rehnström K, Tuulio-Henriksson A, Varilo T, Tallila J, Kristiansson K, Isohanni M, Kaprio J, Eriksson JG, Raitakari OT, Lehtimäki T, Jarvelin MR, Salomaa V, Hurles M, Stefansson H, Peltonen L, Sullivan PF, Paunio T, Lönnqvist J, Daly MJ, Fischer U, Freimer NB, Palotie A
  (See online at https://doi.org/10.1038/nn.3484)
• 2015. LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation. RNA
  Küspert M, Murakawa Y, Schäffler K, Vanselow J, Wolf E, Juranek S, Schlosser A, Landthaler M, Fischer U
  (See online at https://doi.org/10.1261/rna.051441.115)