Intestinal metabolites and their impact on thermogenic responses by brown and white adipose tissues (P02)

• Subject Area: Gastroenterology ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Microbial metabolites such as short-chain fatty acids and bile acids can modulate thermogenic responses in brown and white adipose tissue. The concentration of intestinal metabolites in the systemic circulation is determined by the gatekeeper function of the liver, which thereby controls energy expenditure in brown and beige adipocytes. The relevance of this organ crosstalk to adaptive thermogenesis and systemic energy metabolism will be investigated in the context of a humanized bile acid pool and T cell-mediated inflammation in the liver.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Jörg Heeren; Dr. Dorothee Schwinge