Project Details
Projekt
Development of new functionalized polymer multilayer coating systems and adaptation to additively manufactured degradable implants with complex inner and outer contours
Applicants
Dr. Tonya Andreeva; Professor Dr. Rumen Krastev
Subject Area
Biomaterials
Synthesis and Properties of Functional Materials
Synthesis and Properties of Functional Materials
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 449916462
The aim of Subproject 2 is the development of a biodegradable and biocompatible coating platform to achieve a delayed and controlled degradation of magnesium (Mg)-based biomaterials that meets the regulatory requirements for coatings used in medical implants. A functional composite multilayer coating with protective properties against Mg degradation will be developed, characterized, and applied to the complex surfaces of additively manufactured implants with lattice structures. Our preliminary studies show that composite coatings made from polyelectrolyte multilayers (PEMs) and wax layers offer a promising strategy for controlling the degradation of Mg-based biomaterials. These coatings form nanometre-thick, ultra-smooth, and homogeneous layers, in which the PEM provides a stable, well-adhering matrix for the wax layer. The wax, in turn, forms a hydrophobic barrier that prevents the diffusion of water and corrosive species such as chloride ions. As a result, such coatings protect Mg materials from degradation. As an additional protective measure, gradual crosslinking of the polymer chains in the PEM will increase the packing density and improve the stability of the coating. This will lead to enhanced resistance to the corrosive physiological environment and enable a stepwise degradation profile of both the coating itself and the Mg-based biomaterial. The incorporation of corrosion inhibitors is also planned as an additional means of controlling the degradation rate. Moreover, the PEM/wax composite coating will be used to control biocompatibility. This multi-step approach aims to develop a more robust and biocompatible barrier that enhances the corrosion resistance of Mg alloys and ensures their safe use in biomedical environments.
DFG Programme
Research Units
