G protein-coupled receptors orchestrating granulocytes in pemphigoid diseases (B02)

• Subject Area: Dermatology ; Pharmacology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

The behavior of granulocytes in tissue inflammation is regulated via cell surface receptors. G protein-coupled receptors (GPCRs) constitute the largest group of receptors. The expression of GPCRs is dynamic and determines the stimuli cell populations can respond to in their environment. B02 will profile the expression of GPCRs in granulocytes throughout the effector phase of a pemphigoid disease. Thus, it will identify functional granulocyte subpopulations and highlight stimuli regulating granulocyte behavior in pemphigoid diseases. B02 will uncover the pathogenic significance of select GPCRs for pemphigoid diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• Applicant Institution: Universität zu Lübeck
• Project Heads: Professor Dr. Christian David Sadik; Professorin Dr. Nina Wettschureck