The role of ACTH and glucocorticoid signaling in brown fat metabolism (P12)

• Subject Area: Anatomy and Physiology ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Endocrine signals from the Hypothalamic-Pituitary-Adrenal (HPA) axis control metabolic pathways in many tissues, including brown fat. Indeed, ACTH stimulates, while glucocorticoids inhibit thermogenesis. Here we aim to dissect the physiological effects of the HPA axis on brown fat function. We will decipher the crosstalk between glucocorticoid, ACTH, lipid and cytokine signaling under various conditions such as feeding, cold and high fat diet challenges using mouse genetics, genomics, metabolomics and proteomics. We will determine the relevance of these pathways and their intersection in brown fat function and metabolic disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Yongguo Li; Professorin Dr. Nina Henriette Uhlenhaut