Impact of mitochondrial lipogenesis on thermogenic function and interorganelle crosstalk of brown adipocytes (P15)

• Subject Area: Human Genetics ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Mitochondria are not only the powerhouses of cellular respiration and catabolize different nutrient derivates but are also capable to actively synthesize fatty acids. The role of the mitochondrial derived fatty acids in systemic energy metabolism is unclear. With this project we aim to characterize the function of mitochondrially synthesized fatty acids in the thermogenic function, intracellular energy storage and mitochondrial organelle crosstalk to the endoplasmic reticulum and want to define the impact on whole body metabolic health in mice and humans.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Dr. Christian Schlein