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The role of fatty acid/triglyceride cycling in maintenance of mitochondrial integrity and cellular health, and its contribution to thermogenesis in adipose tissues (P17)

Subject Area Cell Biology
Anatomy and Physiology
Endocrinology, Diabetology, Metabolism
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205
 
Brown adipocytes lacking uncoupling protein 1 (UCP1) recruit a futile fatty acid/triglyceride (FA/TG) cycle for thermogenesis. Futile FA/TG cycling, may control intracellular free fatty acid levels, and thereby avert lipotoxicity. We aim to elucidate the role of the key enzyme DGAT1 (Diacylglycerol-O-Acyltransferase 1) and the peri-lipid droplet mitochondria in FA/TG cycling, and study the impact of FA/TG cycling on the cellular lipidome, organelle and cellular crosstalk, and whole body energy expenditure.
DFG Programme CRC/Transregios
 
 

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