The secret(ory) life of megakaryocytes

• Applicant: Dr. Isabelle Becker
• Subject Area: Cell Biology
• Term: from 2022 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 497998118

• Final Report Year: 2024

No abstract available

Publications

• Don’t you forget about me(gakaryocytes). Blood, 139(22), 3245-3254.
  Tilburg, Julia; Becker, Isabelle C. & Italiano, Joseph E.
  
• Pro-inflammatory megakaryocyte gene expression in murine models of breast cancer. Science Advances, 8(41).
  Roweth, Harvey G.; Malloy, Michael W.; Goreczny, Gregory J.; Becker, Isabelle C.; Guo, Qiuchen; Mittendorf, Elizabeth A.; Italiano, Joseph E.; McAllister, Sandra S. & Battinelli, Elisabeth M.
  
• Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36. Nature Cardiovascular Research, 2(8), 746-763.
  Barrachina, Maria N.; Pernes, Gerard; Becker, Isabelle C.; Allaeys, Isabelle; Hirsch, Thomas I.; Groeneveld, Dafna J.; Khan, Abdullah O.; Freire, Daniela; Guo, Karen; Carminita, Estelle; Morgan, Pooranee K.; Collins, Thomas J. C.; Mellett, Natalie A.; Wei, Zimu; Almazni, Ibrahim; Italiano, Joseph E.; Luyendyk, James; Meikle, Peter J.; Puder, Mark ... & Machlus, Kellie R.
  
• TGFβ1 Secretion in Megakaryocytes Is Autophagy-Dependent and Its Inhibition Ameliorates Myelofibrosis in Mice. Blood, 142(Supplement 1), 744-744.
  Becker, Isabelle C.; Barrachina, Maria N.; Camacho, Virginia; Roweth, Harvey G.; Tilburg, Julia; Chua, Bernadette; Nagy, Zoltan; Englert, Maximilian; Machlus, Kellie R.; Signer, Robert; Nieswandt, Bernhard & Italiano, Joseph E.
  
• A dynamic septin network in megakaryocytes coordinates proplatelet elaboration. Haematologica, 2024. Vol. 109 No. 3.
  Becker I.C., Wilkie A.R., Unger B.A., Sciaudone A.R., Fatima F., Tsai I., Xu K., Machlus K.R. & Italiano J.E.
  
• Cell cycle–dependent centrosome clustering precedes proplatelet formation. Science Advances, 10(25).
  Becker, Isabelle C.; Wilkie, Adrian R.; Nikols, Emma; Carminita, Estelle; Roweth, Harvey G.; Tilburg, Julia; Sciaudone, Anthony R.; Noetzli, Leila J.; Fatima, Farheen; Couldwell, Genevieve; Ray, Anjana; Mogilner, Alex; Machlus, Kellie R. & Italiano, Joseph E.
  
• The bone marrow is the primary site of thrombopoiesis. Blood, 143(3), 272-278.
  Asquith, Nathan L.; Carminita, Estelle; Camacho, Virginia; Rodriguez-Romera, Antonio; Stegner, David; Freire, Daniela; Becker, Isabelle C.; Machlus, Kellie R.; Khan, Abdullah O. & Italiano, Joseph E.