T cells as a therapeutic target in an acute myocardial infarction pig model (A02)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

In this project we will assess novel immunotherapeutic strategies to improve wound healing after myocar- dial infarction (MI). We will mainly use a pig model, allowing us to closely monitor cardiac function under patient-like conditions. To beneficially support wound healing, we are building on our previous work concerning therapeutic T cell targeting. By monitoring T cell activation and differentiation using flow cytometry and scRNA-Seq we will develop a platform for assessing immunomodulatory strategies in MI.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Privatdozent Dr. Niklas Beyersdorf; Privatdozentin Dr. Anna Frey