Pathomechanisms of Immunosenescence in the post-myocardial infarction healing response (A03)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

The prevalence of myocardial diseases increases sharply with age, but most preclinical research in cardiology is conducted in young, healthy animals. Aging is accompanied by accumulating effector T-cells with an inflammatory phenotype that can affect the post-myocardial infarction (MI) healing process. Herein, we will employ several experimental in vivo models to dissect the mechanisms through which immune status al- terations associated with aging, and particularly T-cell immunosenescence, impact the post-MI outcome and the progression of ischemic heart failure.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Georg Gasteiger; Professor Gustavo C. Ramos, Ph.D.