Impact of ischemic cardiomyopathy on haematopoiesis (A07)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

The relationship between systemic leukocytosis and heart failure progression is well documented; however, the underlying mechanisms are still unknown. Preliminary data reveal that bone marrow (BM) angiogenesis post myocardial infarction (MI) is a critical driver of enhanced myelopoiesis. Advanced in vivo and ex vivo/in vitro imaging of murine bone marrow will help elucidate the underlying mechanisms of BM remodelling and its impact on haematopoiesis in chronic heart failure.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professor Dr. David Stegner