Mitochondrial membrane remodelling regulates metabolism and controls innate and adaptive immune responses to myocardial infarction (B05)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

This project aims to uncover the role of dynamic changes in mitochondrial metabolism and phospholipids in controlling the response of macrophages and T-cells to myocardial infarction (MI). The contribution of immune cell metabolism and its impact on their differentiation and effector function in MI remains elusive. A better mechanistic understanding of how structural changes in mitochondria shape inflammatory immune responses will open novel therapeutic avenues for treating immunopathology after MI.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Dr. Jan Alexander Dudek; Martin Väth, Ph.D.