Translating biological binding events into electrical signals using the electrostatically-formed nanowire biologically-modified field-effect transistor

• Applicant: Dr. Sabine Trupp
• Subject Area: Electronic Semiconductors, Components and Circuits, Integrated Systems, Sensor Technology, Theoretical Electrical Engineering ; Biochemistry ; Synthesis and Properties of Functional Materials
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 500240627

Label-free assays can directly measure biologically active molecular interactions and cellular responses, give comprehensive information on the specificity, affinity and in many cases, also the binding kinetics and thermodynamics. A highly pursued platform for specific and label-free probing of the electronic dimensions of biological events is the Biologically-modified Field-effect transistor (BioFET) which has been reported for various materials and designs. The main goal of the current proposal is to perform a thorough, systematic and quantitative examination and to provide a full description as to the mechanism by which the BioFET transduces biological interactions into electronic signals.

• DFG Programme: Research Grants
• International Connection: Israel
• International Co-Applicants: Dr. Barak Akabayov; Dr. Gil Shalev, Ph.D.