Mapping the interdependency of the gut-lung-axis and hydrogel barrier in health and disease (A05)

• Subject Area: Pharmacy
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431232613

We will enhance mucus production in our models. Subsequently, we will explore the repercussions of pathophysiological triggers on the hydrogels. For instance, we will assess the impact of pneumolysin on lung function, introduce bacterial factors to stimulate the intestinal model, and co-culture the model with either probiotic or pathogenic bacteria. Our analysis will focus on understanding how these triggers influence the hydrogel within the affected organ model, and potentially affect the hydrogel in a secondary organ model. In such instances, we will investigate potential mediators of the GLA. Furthermore, we will compare our findings with data from other models and in vivo mouse studies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1449: Dynamic Hydrogels at Biointerfaces
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professorin Dr. Sina Bartfeld; Professorin Dr. Sarah Hedtrich