Systematic investigation of the role of BAF complexes in genome stability (23*)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 393547839

In this project, we aim to systematically investigate the role of different chromatin remodelling complexes and their components in genome protection and repair, with a focus on DNA double-strand breaks (DSBs). We will perform phenotype screening and genome-wide mapping of DSBs in human cell line models with complex subunit perturbations and combine this with proteomics approaches. We will furthermore integrate various published and own 'omics data resources from humans and yeast to identify potential functional relationships and dependencies between chromatin remodelling and genome stability factors. These dependencies will be followed up experimentally and represent potential routes for the therapy of related cancers.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1361: Regulation of DNA Repair and Genome Stability
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Katja Luck; Dr. Sandra Schick-Nickolaus