The role of the Mediator complex in the regulation of enhancer-promoter interactions and gene expression (P02)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 469281184

Mammalian gene expression patterns are regulated by enhancers. To activate genes, enhancers interact with gene promoters in specific 3D chromatin structures. The mechanistic basis of the formation of these structures and enhancer-mediated gene activation is not known. The Mediator complex is thought to play a central role in the transmission of activating signals from enhancers to gene promoters, but its role in the formation of enhancer-promoter interactions remains unclear. The aim of this project is to elucidate the molecular basis of the function of the Mediator complex in regulating enhancer-promoter communication and gene expression patterns during cellular differentiation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1565: Molecular mechanisms and interplay of gene expression processes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Dr. A. Marieke Oudelaar