Cellular mechanisms of intestinal bicarbonate transport: Molecular regulation and physiological function of the apical Cl'/HCOs" exchanger SLC26A6

• Applicant: Professorin Dr. Ursula Seidler
• Subject Area: Gastroenterology
• Term: from 1999 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5160094

• Final Report Year: 2014

No abstract available

Publications

• Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice. Pflügers Archiv - European Journal of Physiology, Vol. 455. 2008, Issue 4, pp 757-766.
  Seidler, Ursula; Rottinghaus, Ingrid; Hillesheim, Jutta; Chen, Mingmin; Riederer, Brigitte; Krabbenhöft, Anja; Engelhardt, Regina; Wiemann, Martin; Wang, Zhaouhui; Barone, Sharon; Manns, Michael P. & Soleimani, Manoocher
  
• CFTR and its key role in in vivo resting and lu-minal acid-induced duodenal HCO3- secretion. Acta Physiologica, Vol. 193. 2008, Issue 4, pp. 357–365.
  Singh, A. K.; Sjöblom, M.; Zheng, W.; Krabbenhöft, A.; Riederer, B.; Rausch, B.; Manns, M. P.; Soleimani, M. & Seidler, U.
  
• Fructose-induced hypertension: essential role of chlo-ride and fructose absorbing transporters PAT1 and Glut5. Kidney International, Vol. 74. 2008, pp. 438–447.
  Singh, Anurag Kumar; Amlal, Hassane; Haas, Patrick J.; Dringenberg, Ulrike; Fussell, Stacey; Barone, Sharon L.; Engelhardt, Regina; Zuo, Jian; Seidler, Ursula & Soleimani, Manoocher
  
• The switch of intestinal Slc26 exchangers from ani-on absorptive to HCO3- secretory mode is dependent on CFTR anion channel function. American Journal of Physiology - Cell Physiology, Vol. 298. 2010, no. 5, C1057-C1065.
  Singh, Anurag Kumar; Riederer, Brigitte; Chen, Mingmin; Xiao, Fang; Krabbenhöft, Anja; Engelhardt, Regina; Nylander, Olof; Soleimani, Manoocher & Seidler, Ursula
  
• New therapeutic targets in ulcerative colitis: the importance of ion transporters in the human colon. Inflammatory Bowel Diseases, Vol. 17. 2011, Issue 4, pp. 884–898.
  Farkas, Klaudia; Yeruva, Sunil; Rakonczay, Zoltán; Ludolph, Lisa; Molnár, Tamás; Nagy, Ferenc; Szepes, Zoltán; Schnúr, Andrea; Wittmann, Tibor; Hubricht, Jessica; Riederer, Brigitte; Venglovecz, Viktória; Lázár, György; Király, Marianna; Zsembery, Ákos; Varga, Gábor; Seidler, Ursula & Hegyi, Péter
  
• Loss of downregulated in adenoma (DRA) impairs mucosal HCO3(-) secretion in murine ileocolonic inflammation. Inflammatory Bowel Diseases, Vol. 18. 2012, Issue 1, pp. 101–111.
  Xiao, Fang; Juric, Marina; Li, Junhua; Riederer, Brigitte; Yeruva, Sunil; Singh, Anurag Kumar; Zheng, Lifei; Glage, Silke; Kollias, George; Dudeja, Pradeep; Tian, De-An; Xu, Gang; Zhu, Jinxia; Bachmann, Oliver & Seidler, Ursula
  
• Telomere shortening is associated with reduced duodenal HCO3- secretory but normal gastric acid secretory capacity in aging mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 303. 2012, no. 12, G1312-G1321.
  Tuo, Biguang; Ju, Zhenyu; Riederer, Brigitte; Engelhardt, Regina; Manns, Michael P.; Rudolph, K. Lenhard & Seidler, Ursula
  
• Increased epithelial permeability is the primary cause for bicarbonate loss in inflamed murine colon. Inflammatory Bowel Diseases, Vol. 19. 2013, Issue 5, pp. 904–911.
  Juric, Marina; Xiao, Fang; Amasheh, Salah; May, Oliver; Wahl, Kristin; Bantel, Heike; Manns, Michael P.; Seidler, Ursula & Bachmann, Oliver
  
• Molecular transport machinery involved in orchestrat-ing luminal acid-induced duodenal bicarbonate secretion in vivo. The Journal of Physiology, Vol. 591. 2013, Issue 21, pp. 5377–5391.
  Singh, Anurag Kumar; Liu, Yongjian; Riederer, Brigitte; Engelhardt, Regina; Thakur, Basant Kumar; Soleimani, Manoocher & Seidler, Ursula
  
• The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine. Pflügers Archiv - European Journal of Physiology, Vol. 466. 2014, Issue 8, pp 1541-1556.
  Xia, Weiliang; Yu, Qin; Riederer, Brigitte; Singh, Anurag Kumar; Engelhardt, Regina; Yeruva, Sunil; Song, Penghong; Tian, De-An; Soleimani, Manoocher & Seidler, Ursula
  
• The PDZ-interaction of the intestinal anion exchanger downregulated in adenoma (DRA; SLC26A3) facilitates its movement into Rab11a-positive recycling endosomes. American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 304. 2013, no. 11, G980-G990.
  Lissner, S.; Hsieh, C.-J.; Nold, L.; Bannert, K.; Bodammer, P.; Sultan, A.; Seidler, U.; Graeve, L. & Lamprecht, G.
  
• Lysophosphatidic acid increases SLC26A3 expression in inflamed intestine and reduces diarrheal severity in C57BL/6 mice with dextran-sodium-sulfateinduced colitis. Chinese Medical Journal, Vol. 127. 2014, Issue 9, pp. 1737-1743.
  Xu L, Xiao F, He J, et al.
  
• Lysophosphatidic acid increases SLC26A3 expression in inflamed intestine and reduces diarrheal severity in C57BL/6 mice with dextran-sodium-sulfateinduced colitis. Chinese Medical Journal, Vol. 127. 2014, Issue 9, pp. 1737-1743.
  Xu L, Xiao F, He J, et al.
  
• Lysophosphatidic acid increases SLC26A3 expression in inflamed intestine and reduces diarrheal severity in C57BL/6 mice with dextran-sodium-sulfateinduced colitis. Chinese Medical Journal, Vol. 127. 2014, Issue 9, pp. 1737-1743.
  Xu L, Xiao F, He J, et al.
  
• Slc26a3 deficiency is associated with loss of colonic HCO3 (-)secretion, absence of a firm mucus layer and barrier impairment in mice. Acta Physiologica, Vol. 211. 2014, Issue 1, pp. 161–175.
  Xiao, F.; Yu, Q.; Li, J.; Johansson, M. E. V.; Singh, A. K.; Xia, W.; Riederer, B.; Engelhardt, R.; Montrose, M.; Soleimani, M.; Tian, D. A; Xu, G.; Hansson, G. C. & Seidler, U.