Age-dependent intestinal epithelial determinants of infections with enteropathogenic Escherichia coli and Campylobacter jejuni (A02)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

Using single cell RNA-seq, A02 aims to identify potential target cell (sub)types that promote or restrict adherence and/or internalisation by enteropathogenic Escherichia coli and Campylobacter jejuni. A02 will investigate underlying molecular mechanisms that mediate age-dependency of these gastrointestinal bacterial infections. In the future, A02 aims to understand which factors shape the age-dependent epithelial determinants and how they can be exploited for therapy development.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professorin Dr. Sina Bartfeld; Professorin Dr. Cynthia Mira Sharma