Mechanisms of infection control by pathogen-educated epithelial-immune cell circuits (A05)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

A05 will investigate ‘specific pathogen experienced’ mice that have undergone a defined series of infections that mimic the “real-world” encounter with frequent human pathogens. A05 will analyse mechanisms mediating resistance and tolerance to infections, studying viral pneumonia induced by Influenza A virus as well as bacterial infection in skin and lung by Staphylococcus aureus. A05 will identify the pathways and cellular interactions that confer resistance to infection in pathogen-experienced epithelial barrier organs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Georg Gasteiger; Professor Dr. Dominic Grün