Mechanisms facilitating local herpes simplex virus replication and control in the female reproductive tract (A07)

• Subject Area: Virology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

A07 will assess the role of type I and III interferons, NF-kB and protein kinase R activation, as well as cell-cell communication in local herpes virus control. Based on differences in the viral gene products identified in different experimental conditions, A07 will identify key host determinants of local infection control. A long-term goal is to provide a mechanistic understanding of decision points for spatial and time-resolved immune control of genital herpes and the role of viral countermeasures thereof.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professor Dr. Lars Dölken