The lung as a pathogen-specific entry site for systemic infection (C03)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

C03 will compare patterns of host pathogen interaction between Staphylococcus aureus and Candida albicans in lung and bloodstream infection and determine molecular decision points governing site-specific entry capacity of these two model pathogens. In addition, C03 will analyse physical and immunological interaction of S. aureus and C. albicans in the lung to identify potential modulatory effects of Candida airway colonisation for the risk for invasive staphylococcal infection.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Oliver Kurzai; Privatdozent Dr. Knut Ohlsen