Nutrition, host metabolism and the antimicrobial response to enteric infection in the neonatal host (A01)

• Subject Area: Immunology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

M. Hornef observed that early-life infection with the human enteropathogen Salmonella impacts on the fetal-neonatal transition of the intestinal epithelium. Early Salmonella infection may therefore influence nutrient digestion, substrate absorption, energy metabolism and microbiota establishment, as well as antimicrobial host defense activation. Based on substantial preliminary and published data, A01 explores molecular mechanisms of these effects and the resulting influence of altered substrate availability on mucosal antimicrobial properties. A01 brings longstanding expertise on mucosal immune development and intestinal infections in neonatal mice, with benefits for many groups working on microbial challenges in barrier tissues.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Mathias Walter Hornef