Immune trajectories defining early lung development in newborn infants (A08)

• Subject Area: Immunology ; Pediatric and Adolescent Medicine
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

A. Hilgendorff and H. Schiller combine complementary expertise on human and mouse neonatal lung development and on transcriptomics in lung cells to study consequences of oxygen therapy and of mechanical forces on the interaction of lung immune and non-immune cells. The project explores mechanisms underlying innate immune cell differentiation in chronic lung disease of preterm infants. A08 will use an existing cohort of preterm infants including longitudinal biomaterial, and a new small prospective cohort. The project offers PILOT models for human “fetal development” ex utero and under physical stress, as well as expertise in multidimensional cellular analysis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Privatdozentin Dr. Anne Hilgendorff; Dr. Herbert Schiller