Role of placenta-derived peptide PIF in perinatal immune cell regulation (B02)

• Subject Area: Immunology ; Anatomy and Physiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

M. Sperandio and R. Immler will exploit their methodological knowledge of intravital imaging and leukocyte recruitment in the fetus to investigate the mechanistic role of the peptide Preimplantation Factor (PIF) in the regulation of maternal and fetal immune cells. The project will evaluate the impact of PIF on fetal immune cell programming and study the regulation of PIF itself during pregnancy. B02 provides unique knowledge in fetal imaging, leukocyte trafficking and neutrophil physiology to PILOT.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Dr. Roland Immler; Professor Dr. Markus Sperandio