Project Details
Projekt Print View

Identification of fibroblast-immune interactions and skin topologies that shape scarless wound repair (B04)

Subject Area Developmental Biology
Immunology
Term since 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693
 
B04 concentrates on fibroblasts and their role in immune cell maturation and function. This proposed work is based on seminal discoveries on fetal fibroblast diversity and function, in particular with respect to scarless wound closure in the fetus, and the role of heterocellular interactions between fibroblasts and neutrophils in scar formation. The impact of fibroblast-immune cell crosstalk on shaping perinatal skin immunity will be explored in terms of fibroblast and connective tissue niche development and adaptation, with a particular focus on the dynamics in stress/injury (in vivo fetal/perinatal skin wound models). These models will be extremely useful for other PILOT groups studying heterocellular interactions in developing tissues.
DFG Programme CRC/Transregios
Applicant Institution Albert-Ludwigs-Universität Freiburg
 
 

Additional Information

Textvergrößerung und Kontrastanpassung