Genetic regulation of protein expression during immune cell development in human neonates (B06)

• Subject Area: Immunology ; Pediatric and Adolescent Medicine
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

B06 will investigate the role of cis-regulatory genetic variants on blood protein expression during perinatal immune cell development in human neonates, by exploiting the Munich Preterm and Term clinical (MUNICH-PreTCl) birth cohort. Next to mass spectrometry-based blood proteomes, genome-wide genotypes of single nucleotide polymorphisms will be generated for proteomic in silico cell type deconvolution of the human neonatal immune system with a focus on neutrophils. This complex basic project with high translational potential will make use of the applicants’ expertise in cell type-interaction expression quantitative trait loci mapping, which will substantially aid other PIs in PILOT in their translational approaches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Dr. Sarah Kim-Hellmuth; Privatdozentin Dr. Claudia Franziska Nußbaum