Project Details
Projekt
Development and functional implications of circadian leukocyte dynamics in early life (B07)
Subject Area
Immunology
Cell Biology
Cell Biology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693
B07 will elucidate how circadian rhythms in myeloid cell function and trafficking are established in the perinatal period. The project will define the time window during which these rhythms develop and explore their relevance in disease. The project is based on previous discoveries of the group concerning steering of leukocyte functions by circadian rhythms. In particular, mechanisms that govern these rhythms in the fetus just before birth and in the neonate will be studied. Finally, the relevance of these rhythms will be explored in a neonatal bacterial sepsis model. B07 contributes outstanding knowledge on the chronobiology of leukocytes and intravital imaging to PILOT.
DFG Programme
CRC/Transregios
Subproject of
TRR 359:
Perinatal Development of Immune Cell Topology
Applicant Institution
Albert-Ludwigs-Universität Freiburg
