Dynamics, epigenetic signatures and modulating factors of tissue Treg cell differentiation (A01)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 490846870

The generation of tissue Treg cells is a stepwise process, and we could recently demonstrate that this is accompanied by extensive epigenome remodeling, finally leading to the acquisition of unique tissue-specific epigenetic signatures. We here aim to characterize the precise dynamics of tissue-seeding and epigenetic remodeling of murine and human tissue Treg cells, and unravel the signals and molecular mechanisms by which these cells acquire and stabilize their unique functional programs. These findings will contribute to the generation of a new class of tissue-specific and functionally adapted Treg cells for future therapeutic applications.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 355: Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Michael Delacher; Professor Dr. Jochen Hühn